Tuesday, January 19, 2016

WILTIMS #416-8: Random fact grabbag

ThursdayIL: Jaundice is first seen at the top of the eye due to that part of the sclera being most hidden from bilirubin-destroying sunlight.

Charcot's triad consists of fever, jaundice, and RUQ (right upper quadrant) pain. Reynolds' pentad consists of the triad plus, hypotension and altered mental status. The triad and the pentad are used to diagnose ascending cholangitis, with the latter being for diagnosing a worsening is the condition.

FridayIL: Clindamycin is the best antibiotic for necrotizing fasciitis because it is both bactericidal (it kills bacteria rather than just preventing their growth) and binds to the toxin that damages the tissue.

In the early stages of diagnosing a patient who might have cancer, try to delicately find out the patient's experience with cancer up to this point. If they do turn out to have cancer, you can better tailor the conversation by knowing if, for example, they have a friend who managed treatment well, or lost a family member who died in pain, or know nothing other than cancer is scary.

TIL: Systemic inflammatory response syndrome (SIRS) is the broader term for the syndrome of sepsis, with or without an infectious source (sepsis is specifically infectious SIRS (confusingly, non-infectious SIRS is just SIRS)).

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