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The above is a concept map that I made during my post-baccalaureate year while studying for the final in a class called Cell Proliferation, Senescence and Death. It was a fascinating, if overwhelming class but boy am I glad to have taken it because, sure enough, the pathways are part of my histology/cell biology class in med school.
My favorite proteins from that chart are Frizzled and Dishevelled, so named because in the Drosophila fly they coordinate the alignment of hairs.
TI(re-)L: Bad/Bid/Puma inhibit Bcl-2 which down-regulates BAX/BAK which causes Apaf to dimerize in the presence of Cytochrome C, activating Caspase-9, leading to the further activation of Caspase-3 which triggers apoptotic cell death, possibly preventing the development of cancer. Simple!
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